Antidepressants then revolutionized the treatment of this disease. Over the past decade, neuroscience and neuroimaging have brought new insights into brain function. It is now possible to visualize the functioning of a healthy brain by its electrical and circulatory manifestations. Any behavior, emotion, or mood change is reflected on the MRI screen by real-time modifications of these transformations. One can visualize the normal activity of a brain and a fortiori the pathological manifestations. For depression, they are identified by areas fixed on the MRI plate.
The disease manifests itself in zones of hyperactivity (frontal) or hypoactivity (left cortical).
At the top, the image, from a functional MRI of a section of a human brain, in a non-depressed subject. At the bottom, during depression, there are hypo-active and hyperactive zones and the metabolism is decreased throughout the cut.
Depression has been shown to be a fixed but reversible transformation of brain activity, accessible by simple, non-invasive methods.
We have gone from the chemical treatment of depression to a functional approach to Transcranial Magnetic Stimulation (SMT).
Magnetic stimulation is the new way of treating mood disorders.