Transmission between nerve cells is provided by chemical substances, neurotransmi tters.Some of these compromised substances have been isolated in depression such as serotonin, dopamine or noradrenaline.
Antidepressants act on the metabolism of these substances and reestablish a compromised balance in depression.
Antidepressants are effective treatments in the treatment
of depressive state. Unfortunately, there are twice as many prescriptions for antidepressants as for depressives. It is this over-consumption, this over-prescription that has brought discredit on the effectiveness of these drugs.
The answer lies in the development of more precise diagnostic tools on the objective criteria of depression (eg polysomnographic recording of sleep).
Antidepressants treat only depression, at the time of depression. As such, they must be kept for a few months unless explicitly prescribed by a psychiatrist.
Thymoregulators are drugs that protect against relapse. They should be prescribed systematically
in case of bipolarity (type 1 or 2) or the risks of bipolarity revealed by the tests and, finally, during recurrent unipolar depressions.
Antidepressants have been an invaluable therapeutic advance. For several generations of patients with unipolar or bipolar depression, they have allowed outpatient treatment, avoid frequent hospitalizations, see definitive after the illness, not to mention suicidal attempts related to this disease. Press campaigns against her medicines stigmatize depressive patients who are obliged to take them and do not prevent those who mistake them from prescribing them.
There are no antidepressants that are really more effective than the others and the laboratories have given up support for their proselytizing on efficacy, rather they put forward the presence of associated (beneficial) effects, Side effects. (Negative)
The general practitioner or psychiatrist has few clinical or examination criteria to choose a particular type of product.
It is often a question of therapeutic habits “the doctor with the experience of this or that drug”, which is not negligible.
Its role is mainly the diagnosis and the decision of prescription.
Its choice is mainly based on side effects, your lifestyle, the effectiveness of previous prescriptions, the place of prescription (hospital / city), a work stoppage …
Most frequently encountered with antidepressants:
Diagnosis: when there is doubt about the effectiveness of the treatment the first precaution is to ensure the diagnosis by the use of instruments, tests and examinations, towards objective signs.
This should be done before prescribing another antidepressant.
Insufficient prescriptions: antidepressants are medicines with a threshold effect. It takes a certain amount in the blood to be sure of the effect, below which they are useless, beyond that they multiply the side effects. This effective range is noted in the Vidal. Forget the phrase “the more we take, the more we take care” or “small depression (depresses) small prescriptions”.
Irregular prescriptions: every other day, a week from time to time, chronic treatment for several years, untimely termination without medical advice …
They often result from self-prescription and they are dangerous.
This “evidence” remains to be demonstrated. No scientific study seems to have highlighted the synergy between two antidepressants. If it does not associate the positive effects, it is likely that it potentiates the side effects.
On the other hand, attention must be paid to the prohibited associations between certain antidepressants.
It should not be done too quickly, effectiveness can be beyond the usual three weeks.
The new antidepressant must belong to another medicinal class, that is to say to have another mechanism of action to increase the chances of success.
Be aware that the chances of success when trying another antidepressant are considerably reduced to 10% success.
No scientific study has ever highlighted the right way to stop an antidepressant. The disastrous announcements are to be discarded. The practice remains in the hands of the general practitioner or the psychiatrist who knows his patient’s susceptibility to drugs and his way of life with.
This medication has “antidepressant” effects and “associated” effects sedative and tranquilizing or conversely psychostimulating and exciting. The antidepressant effect occurs a few weeks later, at least two weeks whereas the associated effects are immediate. These different effects have allowed classification of antidepressants.
From the most tranquilizing to the most psychostimulating.
In addition to the clinical criteria, it is they that determine the choice of your doctor, which will adapt them to your life, your mode of operation and your situation at the time of prescription.
All medications have side effects, although antidepressants are often dramatized by the press. All medications take the physician and patient to the problem of benefit / risk and choice.
Devant l’apparition de nombreux effets secondaires, il faut se poser la question du diagnostic. En effet, il semble que moins la prescription est adaptée et plus les effets secondaires sont présents.
Les effets secondaires vont souvent dans le même sens que les signes de la maladie : Perte de désirs, sensations de distance avec la réalité, diminution de la libido, sentiment de distance avec les autres, fatigabilité, perturbation de la conscience prenant l’apparence du trouble cognitif de la dépression.
Même certains signes physiques des troubles de l’humeur sont communs avec les effets secondaires des antidépresseurs : sécheresse de bouche, constipation, hypotension.
Seules les fringales et la prise de poids semblent s’opposer à l’anorexie, propre au trouble de l’humeur.
What are the most common side effects?